Maternal age affects the relationship of basal FSH and anti-Mullerian hormone concentrations with post-ICSI/IVF live birth
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作者:
Buratini, Jose
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Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Buratini, Jose
[1
,2
]
Dal Canto, Mariabeatrice
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机构:
Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Dal Canto, Mariabeatrice
[2
]
De Ponti, Elena
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机构:
ASST Monza, Dept Med Phys, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
De Ponti, Elena
[3
]
Brambillasca, Fausta
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机构:
Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Brambillasca, Fausta
[2
]
Brigante, Claudio
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Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Brigante, Claudio
[2
]
Gippone, Silvana
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Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Gippone, Silvana
[2
]
Renzini, Mario Mignini
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Reprod Med Ctr, Biogenesi, Monza, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
Renzini, Mario Mignini
[2
]
La Marca, Antonio
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机构:
Clin Eugin, Modena, Italy
Univ Modena & Reggio Emilia, Dept Med & Surg Sci Mother Children & Adults, Modena, ItalySao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
La Marca, Antonio
[4
,5
]
机构:
[1] Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil
[2] Reprod Med Ctr, Biogenesi, Monza, Italy
[3] ASST Monza, Dept Med Phys, Monza, Italy
[4] Clin Eugin, Modena, Italy
[5] Univ Modena & Reggio Emilia, Dept Med & Surg Sci Mother Children & Adults, Modena, Italy
Research question: Does the association of basal FSH and anti-Mullerian hormone (AMH) concentrations with post-IVF/intracytoplasmic sperm injection (ICSI) live birth change with maternal age? Design: A total of 2003 IVF/ICSI patients were stratified according to basal FSH/AMH in concordant favourable (CF; AMH >1 ng/ml and FSH <= 10 IU/l), concordant unfavourable (CU; AMH <= 1 ng/ml and FSH >10 IU/l), discordant with favourable AMH (DFA) and discordant with favourable FSH (DFF) groups, as well as according to age in pre-advanced maternal age (pre-AMA; <35), AMA-1 (>= 35, <= 37), AMA-2 (>37, <= 40) and AMA-3 (>40). IVF/ICSI outcomes were compared among CF, CU, DFA and DFF groups, and the association of basal FSH and AMH concentrations with live birth was tested by univariate and multivariate analysis in total, pre-AMA and AMA groups, separately. Results: Different outcome patterns were observed in discordant AMH/FSH groups from different age categories; favourable basal FSH concentrations were associated with higher delivery rates in pre-AMA patients, but with lower delivery rates in AMA groups. Within pre-AMA patients, DFF patients presented higher delivery rates but lower oocyte yield compared with DFA patients. In the univariate analysis, favourable AMH (P < 0.02) and oocyte yield (P < 0.002) were positively associated with live birth in all AMA groups. The multivariate analysis revealed that favourable basal FSH, but not AMH or oocyte yield, is associated with live birth in pre-AMA patients independently of other variables (P = 0.012). Conclusions: The relationship of basal FSH and AMH with IVF/ICSI success changes with maternal age; basal FSH better reflects clinical outcomes probably determined by oocyte quality in pre-AMA patients, while AMH better suits AMA patients.
机构:
Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Zhao, F.
Wen, D.
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Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Wen, D.
Zeng, L.
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Peking Univ Third Hosp, Clin Epidemiol Res Ctr, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Zeng, L.
Wang, R. Q.
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Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Wang, R. Q.
Li, R.
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Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Li, R.
Chi, H. B.
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Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R ChinaPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
机构:
Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R China
Guo, Yaxin
Liu, Shuai
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Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R China
Liu, Shuai
Hu, Shiqiao
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Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R China
Hu, Shiqiao
Li, Fei
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Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R China
Li, Fei
Jin, Lei
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Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R ChinaHuazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan, Peoples R China
机构:
Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Sao Paulo State Univ, Inst Biosci, Dept Physiol, Sao Paulo, BrazilIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Buratini, J.
Dal Canto, M.
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Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Dal Canto, M.
Brambillasca, F.
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Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Brambillasca, F.
Brigante, C.
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Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Brigante, C.
Gippone, S.
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Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
Gippone, S.
De Ponti, E.
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ASST Monza, Med Phys, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
De Ponti, E.
Renzini, M. M.
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Ist Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, ItalyIst Clin Zucchi, Biogenesi Reprod Med Ctr, Monza, Italy
机构:
New York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USANew York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USA
Huang, Jack Yu Jen
Singer, Tomer
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New York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USANew York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USA
Singer, Tomer
Liu, Hung-Chin
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New York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USANew York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USA
Liu, Hung-Chin
Rosenwaks, Zev
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New York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USANew York Presbyterian Hosp, Weill Cornell Med Coll, Ronald O Perelman & Claudia Cohen Ctr Reprod Med, New York, NY USA