Meiotic inactivation of sex chromosomes in mammals

被引:5
|
作者
Vaskova, E. A. [1 ]
Pavlova, S. V. [1 ]
Shevchenko, A. I. [1 ]
Zakian, S. M. [1 ]
机构
[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia
基金
俄罗斯基础研究基金会;
关键词
MOUSE X-CHROMOSOME; MALE GERMLINE; HISTONE H3; BODY; CHROMATIN; GENES; UBIQUITINATION; SPERMATOGENESIS; MACROH2A1.2; EXPRESSION;
D O I
10.1134/S1022795410040010
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
During meiosis, heteromorphic mammalian X and Y chromosomes in males undergo transcription silencing and form a compact structure, the XY body, containing specific modifications of the chromatin. In this review, we consider the dynamics of sex chromosome inactivation and discuss the suggestion that the paternally inherited X-chromosome preserves inactivated state in zygote. This state results from meiotic silencing and is prone to imprinted inactivation, which is observed in mammalian females at early embryogenetic stages.
引用
收藏
页码:385 / 393
页数:9
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