Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease

被引：52
|
作者：
Du, Guanhua [1 ,2 ]
Sun, Lan [1 ,2 ]
Zhao, Rui [1 ,2 ]
Du, Lida [3 ]
Song, Junke [1 ,2 ]
Zhang, Li [1 ,2 ]
He, Guorong [1 ,2 ]
Zhang, Yongxiang [4 ]
Zhang, Juntian [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing Key Lab Drug Target Res & Drug Screening, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
[4] Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China
来源：
PHARMACOLOGY & THERAPEUTICS | 2016年 / 162卷
基金：
美国国家科学基金会;
关键词：
Ischaemic heart diseases; Polyphenols; Flavonoids; NITRIC-OXIDE SYNTHASE; IMPROVES ENDOTHELIAL FUNCTION; SALVIANOLIC ACID; PROTECTS CARDIOMYOCYTES; IN-VITRO; REPERFUSION INJURY; OXIDATIVE STRESS; PRESSURE-OVERLOAD; INDUCED APOPTOSIS; PLATELET-FUNCTION;
D O I：
10.1016/j.pharmthera.2016.04.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Polyphenols, which are naturally present in plants, have been studied for their chemical and pharmacological properties. Polyphenols have been found to exhibit various bioactivities such as antioxidant, free radical scavenging and anti-inflammatory effects, in addition to regulating the intracellular free calcium levels. These bioactivities are related to the underlying mechanisms of ischaemic heart diseases. Pharmacological studies have proven polyphenols to be effective in treating cardiovascular diseases in various ways, particularly ischaemic heart diseases. Based on their mode of action, we propose that some polyphenols can be developed as drugs to treat ischaemic heart diseases. For this purpose, a strategy to evaluate the therapeutic value of drugs for ischaemic heart diseases is needed. Despite several advances in percutaneous coronary intervention (PCI), the incidence of myocardial infarction and deaths due to cardiovascular diseases has not decreased markedly in China. Due to their pleiotropic properties and structural diversity, polyphenols have been of great interest in pharmacology. In the present review, we summarize the pharmacological effects and mechanisms of polyphenols reported after 2000, and we analyse the benefits or druggability of these compounds for ischaemic heart diseases. (C) 2016 Elsevier Inc. All rights reserved.
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页码：23 / 34
页数：12
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