Analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in biological samples by gas chromatography tandem mass spectrometry (GC/MS-MS)

被引：42
|
作者：
Chiarotti, M
Costamagna, L
机构：
[1] Univ Cattolica Sacro Cuore, Inst Forens Med, I-00168 Rome, Italy
[2] Univ Roma La Sapienza, Inst Forens Med, Rome, Italy
来源：
FORENSIC SCIENCE INTERNATIONAL | 2000年 / 114卷 / 01期
关键词：
11-nor-carboxy-Delta(9)-tetrahydrocannabinol; cannabis; GC/MS-MS analysis; biological samples; drug testing;
D O I：
10.1016/S0379-0738(00)00248-6
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Gas chromatography tandem mass spectrometry (GC/MS-MS) analysis of 11-nor-carboxy-Delta(9)-tetrahydrocannabinol (Delta(9)-THC-COOH), the major or metabolite of Delta(9)-tetrahydrocannabinol, in biological samples is reported. The proposed method, using deuterated Delta(9)-THC-COOH as an internal standard, is able to detect the major metabolite of cannabis derivatives at very low levels (picograms/millilitre) with high specificity. These characteristics render the proposed analytical procedure suitable for confirmatory analysis in drug testing for cannabis use. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：1 / 6
页数：6
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