The identification, development and therapeutic potential of IL-10-producing regulatory B cells in multiple sclerosis

被引：5
|
作者：
Xiang, Weiwei [1 ]
Xie, Chong [1 ]
Guan, Yangtai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurol, 160 Pujian Rd, Shanghai 200127, Peoples R China
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 354卷
基金：
中国国家自然科学基金;
关键词：
Regulatory B cells; B10; cells; Interleukin-10; Multiple sclerosis; Therapeutic strategy; B10; CELLS; IL-10; PRODUCTION; 1,25-DIHYDROXYVITAMIN D-3; NEUROMYELITIS-OPTICA; TOLERANCE INDUCTION; ANTIGEN RECEPTOR; SUBSETS; INTERLEUKIN-10; DISEASE; ENCEPHALOMYELITIS;
D O I：
10.1016/j.jneuroim.2021.577520
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory B cells are a rare B-cell subset widely known to exert their immunosuppressive function via the production of interleukin-10 (IL-10) and other mechanisms. B10 cells are a special subset of regulatory B cells with immunoregulatory function that is fully attributed to IL-10. Their unique roles in the animal model of multiple sclerosis (MS) have been described, as well as their relevance in MS patients. This review specifically focuses on the identification and development of B10 cells, the signals that promote IL-10 production in B cells, the roles of B10 cells in MS, and the potential and major challenges of the application of B10-based therapies for MS.
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页数：9
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