Rh-Catalyzed General Method for Directed C-H Functionalization via Decarbonylation of in-Situ-Generated Acid Fluorides from Carboxylic Acids

被引：10
|
作者：
He, Bangyue [1 ,2 ]
Liu, Xiaojie [1 ]
Li, Hongyi [1 ]
Zhang, Xiaofeng [1 ]
Ren, Yuxi [1 ]
Su, Weiping [1 ,2 ]
机构：
[1] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 11期
基金：
中国国家自然科学基金;
关键词：
DECARBOXYLATION; ALKYLATION; ACTIVATION; ARYLATION; AMIDES; BONDS;
D O I：
10.1021/acs.orglett.1c01103
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Rh-catalyzed decarbonylative C-H coupling of in-situ-generated acid fluorides with amide substrates bearing ortho-Csp(2)-H bonds has been developed. This method enables alkyl, aryl, and alkenyl carboxylic acids to undergo decarbonylative coupling with C-H bonds of (hetero)aromatic or alkenyl amides in generally good yields via the in situ conversion of carboxylic acids into acid fluorides and also allows for the functionalization of a series of structurally complex carboxyl-containing natural products and pharmaceuticals as well as pharmaceutical amide derivatives.
引用
收藏
页码：4191 / 4196
页数：6
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