The Path of Most Resistance: Transdifferentiation Underlies exceptional nonresponses to Androgen Receptor Pathway Inhibition in Prostate Cancer

被引：7
|
作者：
Sinha, Seema
Nelson, Peter S.
机构：
[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
来源：
CANCER DISCOVERY | 2017年 / 7卷 / 07期
关键词：
ANTIANDROGEN RESISTANCE; LINEAGE PLASTICITY;
D O I：
10.1158/2159-8290.CD-17-0481
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Discovery, Zou and colleagues describe a mechanism involving cellular transdifferentiation that promotes exceptional resistance to antiandrogen therapy in prostate cancer. A background of coinactivation of Trp53 and Pten increased the frequency of the transdifferentiated neuroendocrine phenotype. These findings have implications for developing approaches to repress cellular plasticity and overcome treatment resistance. (C) 2017 AACR.
引用
收藏
页码：673 / 674
页数：2
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