YY1 transcription factor down-regulates expression of CCR5, a major coreceptor for HIV-1

被引：15
|
作者：
Moriuchi, M
Moriuchi, H
机构：
[1] Nagasaki Univ Hosp, Dept Pediat, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Sch Biomed Sci, Div Med Virol, Dept Mol Microbiol & Immunol, Nagasaki 8528523, Japan
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2003年 / 278卷 / 15期
关键词：
D O I：
10.1074/jbc.M204980200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of CCR5, a major coreceptor for human immunodeficiency virus type 1 (HIV-1), is regulated by a number of transcription factors. Here we report that the YY1 transcription factor down-regulates CCR5 promoter activity and that overexpression of YY1 reduces cell surface CCR5 expression and infectibility by R5-HIV-1. Because YY1 also down-regulates promoter activities of CXCR4, another major coreceptor for HIV-1 and HIV-1 long terminal repeat, this transcription factor may play a critical role in the pathogenesis of HIV-1 disease.
引用
收藏
页码：13003 / 13007
页数：5
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