Birth and Death of Histone mRNAs

被引：138

作者：

Marzluff, William F. ^{[1
,2
,3
]}

Koreski, Kaitlin P. ^{[1
,3
]}

机构：

[1] Univ N Carolina, Integrat Program Biol & Genome Sci, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

来源：

TRENDS IN GENETICS | 2017年 / 33卷 / 10期

基金：

美国国家卫生研究院;

关键词：

LOOP-BINDING-PROTEIN; POLYADENYLATION FACTOR CPSF-73; CYCLIN E/CDK2 SUBSTRATE; CELL-CYCLE; STEM-LOOP; 3' END; LOCUS BODY; GENE-TRANSCRIPTION; S-PHASE; CAJAL BODY;

D O I：

10.1016/j.tig.2017.07.014

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In metazoans, histone mRNAs are not polyadenylated but end in a conserved stem-loop. Stem-loop binding protein (SLBP) binds to the stem-loop and is required for all steps in histone mRNA metabolism. The genes for the five histone proteins are linked. A histone locus body (HLB) forms at each histone gene locus. It contains factors essential for transcription and processing of histone mRNAs, and couples transcription and processing. The active form of U7 snRNP contains the HLB component FLASH (FLICE-associated huge protein), the histone cleavage complex (HCC), and a subset of polyadenylation factors including the endonuclease CPSF73. Histone mRNAs are rapidly degraded when DNA replication is inhibited by a 30 to 50 pathway that requires extensive uridylation of mRNA decay intermediates.

引用

页码：745 / 759

页数：15

共 50 条

[1] Following the Birth, Life, and Death of mRNAs in Single Cells
Eichenberger, Bastian T.
Griesbach, Esther
Mitchell, Jessica
Chao, Jeffrey A.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2023, 39 : 253 - 275
[2] From birth to death: The complex lives of eukaryotic mRNAs
Moore, MJ
SCIENCE, 2005, 309 (5740) : 1514 - 1518
[3] Following Single mRNAs from Birth to Death in Living Cells
Singer, Robert H.
Lionnet, Timothee
Park, Hye Yoon
Wu, Bin
Trcek, Tatjana
Hocine, Sami
Larson, Daniel
BIOPHYSICAL JOURNAL, 2012, 102 (03) : 609A - 610A
[4] Following single mRNAs from birth to death in living cells and tissues
Singer, Robert
CANCER RESEARCH, 2013, 73 (08)
[5] Following Single mRNAs from Birth to Death in Living Cells.
Singer, R. H.
MOLECULAR BIOLOGY OF THE CELL, 2016, 27
[6] Cotranscriptional processing of Drosophila histone mRNAs
Adamson, TE
Price, DH
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (12) : 4046 - 4055
[7] DEATH IS BIRTH AND BIRTH IS DEATH - PARASCIENTIFIC UNDERSTANDING OF DEATH AND BIRTH
LEE, JY
SYSTEMATICS, 1972, 9 (04): : 188 - 200
[8] Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye
Hoefig, Kai P.
Heissmeyer, Vigo
WILEY INTERDISCIPLINARY REVIEWS-RNA, 2014, 5 (04) : 577 - 589
[9] Birthing histone mRNAs by CSR-1 section
Pasquinelli, Amy E.
EMBO JOURNAL, 2012, 31 (19): : 3790 - 3791
[10] E pluribus unum:: 3′ end formation of polyadenylated mRNAs, histone mRNAs, and U snRNAs
Weiner, AM
MOLECULAR CELL, 2005, 20 (02) : 168 - 170

← 1 2 3 4 5 →