Recent Progress of Src SH2 and SH3 Inhibitors as Anticancer Agents

被引：14

作者：

Lu, X. -L. ^{[1
]}

Cao, X. ^{[2
]}

Liu, X. -Y. ^{[1
]}

Jiao, B. -H. ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Biochem & Mol Biol, Fac Basic Med Sci, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 12期

关键词：

Protein tyrosine kinases; Src kinases; SH2; SH3; inhibitor; peptidomimetic; nonpeptide; progress; GROWTH-FACTOR RECEPTOR; STRUCTURE-BASED DESIGN; NONPEPTIDE INHIBITORS; TYROSINE KINASE; SMALL-MOLECULE; ACTIVATED SRC; LIGANDS; CELL; BINDING; CANCER;

D O I：

10.2174/092986710790827861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Src family tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. For both Src SH2 and SH3 domains involve in the regulation of tumorigenesis signal pathways, the SH2 and SH3 inhibition strategies are expected to block the protein-protein interactions between SFKs and their corporation proteins to abolish the signal transduction. Many inhibitors of SH2 and SH3 domain have been identified. Herein, some predominant examples of these inhibitors are reviewed.

引用

页码：1117 / 1124

页数：8

共 50 条

[1] SH2 AND SH3 DOMAINS
PAWSON, T
SCHLESSINGER, J
CURRENT BIOLOGY, 1993, 3 (07) : 434 - 442
[2] Cooperative activation of Src family kinases by SH3 and SH2 ligands
Yadav, Shalini S.
Miller, W. Todd
CANCER LETTERS, 2007, 257 (01) : 116 - 123
[3] SH2 AND SH3 DOMAINS - POTENTIAL TARGETS FOR ANTICANCER DRUG DESIGN
SMITHGALL, TE
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1995, 34 (03) : 125 - 132
[4] STRUCTURES OF SH2 AND SH3 DOMAINS
KURIYAN, J
COWBURN, D
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (06) : 828 - 837
[5] SH2/SH3 SIGNALING PROTEINS
SCHLESSINGER, J
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (01) : 25 - 30
[6] Functions of SH2 and SH3 domains
Mayer, BJ
Gupta, R
PROTEIN MODULES IN SIGNAL TRANSDUCTION, 1998, 228 : 1 - 22
[7] Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions
Groveman, Bradley R.
Xue, Sheng
Marin, Vedrana
Xu, Jindong
Ali, Mohammad K.
Bienkiewicz, Ewa A.
Yu, Xian-Min
FEBS JOURNAL, 2011, 278 (04) : 643 - 653
[8] SH2 and SH3 domains as targets for anti-proliferative agents
Vidal, M
Gigoux, V
Garbay, C
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2001, 40 (02) : 175 - 186
[9] Interactions between SH2 and SH3 domains
Vihinen, M
Smith, CIE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 242 (02) : 351 - 356
[10] SH2 SH3 - EXPLORATION OF NEW DOMAINS
MOORE, B
SEROUSSI, G
JOCHIM, B
M S-MEDECINE SCIENCES, 1993, 9 (6-7): : 788 - 790

← 1 2 3 4 5 →