MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

被引：79
|
作者：
Kalafatovic, Daniela [1 ]
Nobis, Max [2 ]
Javid, Nadeem [1 ]
Frederix, Pim W. J. M. [1 ]
Anderson, Kurt I. [2 ]
Saunders, Brian R. [3 ]
Ulijn, Rein V. [1 ,4 ,5 ]
机构：
[1] Univ Strathclyde, Dept Pure & Appl Chem, West CHEM, Glasgow G1 1XL, Lanark, Scotland
[2] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
[3] Univ Manchester, Sch Mat, Manchester M1 7HS, Lancs, England
[4] CUNY, ASRC, New York, NY 10031 USA
[5] CUNY, Hunter Coll, Dept Chem & Biochem, New York, NY 10065 USA
来源：
BIOMATERIALS SCIENCE | 2015年 / 3卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
PEPTIDE AMPHIPHILES; SMALL MOLECULES; MATRIX METALLOPROTEINASES; CLEAVAGE SITES; HYDROGELS; CANCER; SUBSTRATE; DESIGN; CELLS; NANOSTRUCTURES;
D O I：
10.1039/c4bm00297k
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
引用
收藏
页码：246 / 249
页数：4
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