Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

被引：144
|
作者：
Sreenilayam, Gopeekrishnan [1 ]
Fasan, Rudi [1 ]
机构：
[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 08期
关键词：
HIGHLY ENANTIOSELECTIVE INSERTION; ALPHA-AMINO-ACIDS; DIAZO-COMPOUNDS; OLEFIN CYCLOPROPANATION; O-H; BONDS; COMPLEXES; ESTERS; ROUTE; DERIVATIVES;
D O I：
10.1039/c4cc08753d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of alpha-diazo esters into the N-H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.
引用
收藏
页码：1532 / 1534
页数：3
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