Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone

被引：1
|
作者：
Xu, Qian [1 ]
Wang, Li-Na [1 ]
Zhao, Jing-Yi [1 ]
Xiao, Yan-Hong [1 ]
Du, Chao [1 ]
机构：
[1] Chengde Med Univ, Dept Biochem, Chengde 067000, Hebei, Peoples R China
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2021年 / 16卷 / 02期
关键词：
FIBROSIS; CELLS; SPIRONOLACTONE; EXPRESSION; INFARCTION; PATHWAYS; MUSCLE;
D O I：
10.3329/bjp.v16i2.51605
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to explore the possible molecular mechanisms of paeonol in preventing ventricular remodeling. The cell viability of neonatal rat cardiac fibroblasts was detected by the method of MTT. RT-PCR and Western blot were used to measure the expression of TGF-beta 1, type I collagen and type III collagen. After treating the cardiac fibroblasts with paeonol, the cell viability decreased (p<0.01), and the expression of TGF-beta 1, type I collagen and types III collagen was significantly reduced (p<0.01). Thus, paeonol can inhibit the proliferation of fibroblast cells induced by aldosterone. The molecular mechanism is related to the down-regulation of TGF-beta(1) and type I and III collagen gene expression.
引用
收藏
页码：42 / 48
页数：7
相关论文
共 50 条
  • [1] Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
    Rombouts, K
    Wielant, A
    Hellemans, K
    Schuppan, D
    Geerts, A
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (01) : 224 - 232
  • [2] Effects of Visfatin on Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts
    Yu, X-Y.
    Qiao, S-B.
    Guan, H-S.
    Liu, S-W.
    Meng, X-M.
    HORMONE AND METABOLIC RESEARCH, 2010, 42 (07) : 507 - 513
  • [3] Effects of Paeonol on Expression of Type Ⅰ and Type Ⅲ Collagen of High Glucose Induced Proliferation of Cardiac Fibroblasts
    Dandan WU
    Xiaohui ZHOU
    Medicinal Plant, 2019, (06) : 94 - 96
  • [4] Effects of adrenomedullin on aldosterone-induced cell proliferation in rat cardiac fibroblasts
    Jiang, W
    Yang, JH
    Wang, SH
    Pan, CS
    Qi, YF
    Zhao, J
    Tang, CS
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2004, 1690 (03): : 265 - 275
  • [5] Effects of Lovastatin on the proliferation and cell cycle of rat cardiac fibroblasts induced by aldosterone in vitro
    Cui, W
    Fang, HP
    Shan, B
    Hao, YM
    Du, J
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (03) : 394A - 394A
  • [6] The effect of testosterone on the angiotensinII induced proliferation and collagen synthesis in neonatal rat cardiac fibroblasts
    Sun Lina
    Yan Shuxun
    Wang Ying
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (16) : C18 - C18
  • [7] ALDOSTERONE AND COLLAGEN-SYNTHESIS IN CULTURED ADULT-RAT CARDIAC FIBROBLASTS
    BRILLA, CG
    ZHOU, G
    WEBER, KT
    FASEB JOURNAL, 1992, 6 (05): : A1914 - A1914
  • [8] Effect of testosterone on the proliferation and collagen synthesis of cardiac fibroblasts induced by angiotensin II in neonatal rat
    Yang, Xiaocun
    Wang, Ying
    Yan, Shuxun
    Sun, Lina
    Yang, Guojie
    Li, Yuan
    Yu, Chaonan
    BIOENGINEERED, 2017, 8 (01) : 14 - 20
  • [9] Inhibitory Effects of Momordicine I on High-Glucose-Induced Cell Proliferation and Collagen Synthesis in Rat Cardiac Fibroblasts
    Chen, Po-Yuan
    Shih, Neng-Lang
    Hao, Wen-Rui
    Chen, Chun-Chao
    Liu, Ju-Chi
    Sung, Li-Chin
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
  • [10] Effect of phosphocreatine on angiotensininIIinduced proliferation and collagen synthesis in neonatal rat cardiac fibroblasts
    Wei, Zihan
    Wang, Ying
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 66 (16) : C228 - C228
12345