Bridging intestinal immunity and gut microbiota by metabolites

被引：202

作者：

Wang, Gang ^{[1
,2
]}

Huang, Shuo ^{[1
,2
]}

Wang, Yuming ^{[1
,2
]}

Cai, Shuang ^{[1
,2
]}

Yu, Haitao ^{[1
,2
]}

Liu, Hongbing ^{[1
,2
]}

Zeng, Xiangfang ^{[1
,2
]}

Zhang, Guolong ^{[3
]}

Qiao, Shiyan ^{[1
,2
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

[2] China Agr Univ, Beijing Key Lab Biol Feed Addit, Beijing 100193, Peoples R China

[3] Oklahoma State Univ, Dept Anim Sci, Stillwater, OK 74074 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2019年 / 76卷 / 20期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Fecal microbiota transplantation; Innate and adaptive immune cells; Germ-free animals; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; INNATE LYMPHOID-CELLS; AROMATIC-AMINO-ACIDS; BILE-ACIDS; URSODEOXYCHOLIC ACID; DENDRITIC CELLS; CHENODEOXYCHOLIC ACID;

D O I：

10.1007/s00018-019-03190-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the development and function of the gut-specific immune system, and provides some protection from infectious pathogens. However, interactions between intestinal immunity and microorganisms are very complex, and recent studies have revealed that this intimate crosstalk may depend on the production and sensing abilities of multiple bioactive small molecule metabolites originating from direct produced by the gut microbiota or by the metabolism of dietary components. Here, we review the interplay between the host immune system and the microbiota, how commensal bacteria regulate the production of metabolites, and how these microbiota-derived products influence the function of several major innate and adaptive immune cells involved in modulating host immune homeostasis.

引用

页码：3917 / 3937

页数：21

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