Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring

被引：48

作者：

Al Jishi, Taher ^{[1
,2
,3
]}

Sergi, Consolato ^{[1
,4
,5
]}

机构：

[1] Univ Alberta, Dept Lab Med & Pathol, 8440-112 St, Edmonton T6G 2B7, AB, Canada

[2] Univ Ottawa, Fac Med, OMNI Res Grp, Dept Obstet & Gynecol, Ottawa, ON, Canada

[3] Ottawa Hosp, Res Inst, Box 241,501 Smyth Rd, Ottawa K1H 8L6, ON, Canada

[4] Stollery Childrens Hosp, 8440 112 St, Edmonton, AB T6G 2B7, Canada

[5] Wuhan Univ Sci & Technol, Tianyou Hosp, Wuhan, Hubei, Peoples R China

来源：

REPRODUCTIVE TOXICOLOGY | 2017年 / 71卷

关键词：

Diethylstibestrol; Pregnancy loss; First trimester; Congenital birth defects; Cancer; CLEAR-CELL ADENOCARCINOMA; MATERNAL STILBESTROL THERAPY; EARLY-LIFE EXPOSURES; IN-UTERO; BISPHENOL-A; BREAST-CANCER; VAGINAL ADENOSIS; PRENATAL EXPOSURE; GENE-EXPRESSION; GENITAL-TRACT;

D O I：

10.1016/j.reprotox.2017.04.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diethylstilbestrol (DES) was an orally active estrogen prescribed to the pregnant women to prevent miscarriages. DES is known as a 'biological time bomb' and long-term effects of DES have been recorded in the mothers exposed to DES and their offspring (DES-daughters and DES-sons). Adverse pregnancy outcomes, infertility, cancer, and early menopause have been discovered in women exposed to DES, and some events occur in their offspring and subsequent generations. An increased risk of breast cancer is not limited to the DES-exposed daughters. There is an urgent need to find ways to stop the inheritance cycle of DES and prevent adverse effects of DES in the future generations. The present article reviews the health implications of DES exposure and screening exams currently recommended to DES daughters and their offspring. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：71 / 77

页数：7

共 50 条

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