Targeting tumor-associated macrophages in cancer therapy and understanding their complexity

被引：26
|
作者：
Cannarile, Michael A. [1 ]
Ries, Carola H. [1 ]
Hoves, Sabine [1 ]
Ruettinger, Dominik [1 ]
机构：
[1] Roche Innovat Ctr Penzberg, Roche Pharmaceut Res & Early Dev, Discovery Oncol, Penzberg, Germany
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 09期
关键词：
tumor-associated macrophages; CSF-1R; RG7155; TAM depletion; myeloid cells;
D O I：
10.4161/21624011.2014.955356
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophage infiltration has been identified as an independent, poor prognostic factor for patients afflicted with various cancer entities. However, the characterization of tumor-associated macrophages (TAMs) prior to and following cancer patient treatment has been limited. Our study analyzed tumor biopsies before and after anti-CSF-1R antibody treatment unraveling the nature of TAMs and providing novel insights into their phenotypic and functional characteristics in cancer.
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页数：2
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