Protein tyrosine kinases and cancer

被引:140
|
作者
Kolibaba, KS
Druker, BJ [1 ]
机构
[1] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97201 USA
[3] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Portland, OR 97201 USA
来源
关键词
D O I
10.1016/S0304-419X(97)00022-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ABL, PDGFR, RET, and ALK tyrosine kinases have been clearly implicated in the etiology of human malignancies. However, in other tumors, distinguishing between tyrosine kinases as causative agents, as opposed to markers of disease progression or reflections of aberrant tumor cells, has proven difficult. In the absence of a genetic mutation in a tyrosine kinase, it has been difficult to confirm a role for various tyrosine kinases in most malignant human diseases. Given the central role of tyrosine kinases in the control of cellular growth and differentiation, however, it is likely that tyrosine kinases will be shown to participate in crucial aspects of tumorigenesis, some of which may provide fruitful avenues for therapeutic intervention.
引用
收藏
页码:F217 / F248
页数:32
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