Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

被引：0

作者：

Mumtaz, Amina ^{[1
]}

Mahmud, Tariq ^{[2
]}

Elsegood, M. R. J. ^{[3
]}

Weaver, G. W. ^{[3
]}

机构：

[1] PCSIR Labs Complex, Ferozepur Rd, Lahore, Pakistan

[2] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[3] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

REVISTA DE CHIMIE | 2018年 / 69卷 / 07期

关键词：

Schiff base; metal complex; sulphadizine; Pyridoxal hydrochloride; Antibacterial; ANTIBACTERIAL AGENTS SYNTHESIS; CO(II) COMPLEXES; COPPER; SULFAMETHOXAZOLE; HYDRAZONE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

引用

页码：1678 / 1681

页数：4

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