The tissue-specific methylation of human-specific endogenous retroviral LTRs

被引：1
|
作者：
Khodosevich, KV [1 ]
Lebedev, YB [1 ]
Sverdlov, ED [1 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinninov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2004年 / 30卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
endogenous retroviruses; gene expression; human genome evolution; methylation;
D O I：
10.1023/B:RUBI.0000043787.07628.2a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study.
引用
收藏
页码：441 / 445
页数：5
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