Toxic effector molecules in the pathogenesis of immune-mediated disorders of the central nervous system

被引：0
|
作者：
Kieseier, BC [1 ]
Storch, MK [1 ]
Hartung, HP [1 ]
机构：
[1] Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria
来源：
JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 2000年 / 59期
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D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A growing body of evidence supports the notion that inflammatory reactions in the central nervous system (CNS) are not only restricted to established immune mediated disorders, such as multiple sclerosis, but also contribute to the pathogenesis of Alzheimer's disease and other types of neurodegenerative disorders. The biological roles of toxic mediators, such as nitric oxide, reactive oxygen species, as well as complement and proteases in the genesis of inflammatory reactions in the CNS are reviewed within the context of demyelination and neuronal damage.
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页码：69 / 80
页数：12
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