Selective repression of c-fos gene transcription in rat embryo fibroblasts transformed by oncogenes E1A and cHa-ras

被引：4

作者：

Abramova, MV ^{[1
]}

Kukushkin, AN ^{[1
]}

Svetlikova, SB ^{[1
]}

Pospelova, TV ^{[1
]}

Pospelov, VA ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 306卷 / 02期

关键词：

c-fos repression; histone deacetylase; chromatin remodeling; sodium butyrate; E1A and ras oncogenes;

D O I：

10.1016/S0006-291X(03)00996-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transformation of REF cells by oncogenes E1A and cHa-ras leads to activation of AP-1 factor concomitantly with downregulation of c-fos gene transcription. Here we addressed two issues: (i) how does transcription of Fos/Jun-regulated genes change in the cells lacking Fos-Jun heterodimers; (ii) to which extent HDAC-mediated chromatin reorganization does affect, apart from c-fos, transcription of some other early and late-response genes. To this end, we studied the kinetics of serum-stimulated transcription of c-fos, c-jun, fra-1, egr-1, and cyclinD1 genes, as well as the effects of sodium butyrate, an inhibitor of histone deacetylase activity, on transcription of these genes in normal REF cells and transformants E1A + ras. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：483 / 487

页数：5

共 47 条

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Kukushkin, AN
Abramova, MV
Svetlikova, SB
Darieva, ZA
Pospelova, TV
Pospelov, VA
ONCOGENE, 2002, 21 (05) : 719 - 730
[2] Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter
Alexander N Kukushkin
Maria V Abramova
Svetlana B Svetlikova
Zalfia A Darieva
Tatiana V Pospelova
Valery A Pospelov
Oncogene, 2002, 21 : 719 - 730
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Kukushkin A.N.
Svetlikova S.B.
Pospelov V.A.
Cell and Tissue Biology, 2014, 8 (2) : 115 - 121
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A. N. Kukushkin
S. B. Svetlikova
V. A. Pospelov
Molecular Biology, 2005, 39 : 69 - 76
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Kukushkin, AN
Svetlikova, SB
Pospelov, VA
MOLECULAR BIOLOGY, 2005, 39 (01) : 69 - 76
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[9] Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells
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ONCOGENE, 2003, 22 (48) : 7661 - 7666
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Tatiana Usenko
Alexander Kukushkin
Tatiana Pospelova
Valery Pospelov
Oncogene, 2003, 22 : 7661 - 7666

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