Kinetic mechanism of Ras.GTP hydrolysis catalyzed by the GAP, neurofibromin.

被引：0
|
作者：
Phillips, RA [1 ]
Eccleston, JF [1 ]
Webb, MR [1 ]
机构：
[1] Natl Inst Med Res, London NW7 1AA, England
来源：
BIOPHYSICAL JOURNAL | 2003年 / 84卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
引用
收藏
页码：39A / 39A
页数：1
相关论文
共 50 条
  • [1] THE KINETIC MECHANISM OF THE GAP CATALYZED-HYDROLYSIS OF GTP BY P21N-RAS
    ECCLESTON, JF
    MOORE, KJM
    LOWE, PN
    FASEB JOURNAL, 1992, 6 (01): : A97 - A97
  • [2] Hydrolysis of Guanosine Triphosphate (GTP) by the Ras•GAP Protein Complex: Reaction Mechanism and Kinetic Scheme
    Khrenova, Maria G.
    Grigorenko, Bella L.
    Kolomeisky, Anatoly B.
    Nemukhin, Alexander V.
    JOURNAL OF PHYSICAL CHEMISTRY B, 2015, 119 (40): : 12838 - 12845
  • [3] MECHANISM OF GTP HYDROLYSIS BY P21(N-RAS) CATALYZED BY GAP - STUDIES WITH A FLUORESCENT GTP ANALOG
    MOORE, KJM
    WEBB, MR
    ECCLESTON, JF
    BIOCHEMISTRY, 1993, 32 (29) : 7451 - 7459
  • [4] A mechanism of catalyzed GTP hydrolysis by Ras protein through magnesium ion
    Lu, Qiang
    Nassar, Nicolas
    Wang, Jin
    CHEMICAL PHYSICS LETTERS, 2011, 516 (4-6) : 233 - 238
  • [5] QM/MM Study on the GTP hydrolysis catalyzed by the Ras-GAP protein complex
    Higashi, Masahiro
    Kobayashi, Chigusa
    Saito, Shinji
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
  • [6] Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: Evidence for a loose transition state
    Du, XL
    Black, GE
    Lecchi, P
    Abramson, FP
    Sprang, SR
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (24) : 8858 - 8863
  • [7] Study of Ras catalytic mechanism of intrinsic hydrolysis of GTP
    Knihtila, Ryan
    Holzapfel, Genevieve
    Mattos, Carla
    FASEB JOURNAL, 2013, 27
  • [8] GTP hydrolysis mechanism of Ras-like GTPases
    Li, GP
    Zhang, XJC
    JOURNAL OF MOLECULAR BIOLOGY, 2004, 340 (05) : 921 - 932
  • [9] Molecular Mechanism for Conformational Dynamics of Ras.GTP Elucidated from In-Situ Structural Transition in Crystal
    Matsumoto, Shigeyuki
    Miyano, Nao
    Baba, Seiki
    Liao, Jingling
    Kawamura, Takashi
    Tsuda, Chiemi
    Takeda, Azusa
    Yamamoto, Masaki
    Kumasaka, Takashi
    Kataoka, Tohru
    Shima, Fumi
    SCIENTIFIC REPORTS, 2016, 6
  • [10] KINETIC-ANALYSIS OF THE HYDROLYSIS OF GTP BY P21N-RAS - THE BASAL GTPASE MECHANISM
    NEAL, SE
    ECCLESTON, JF
    HALL, A
    WEBB, MR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (36) : 19718 - 19722
12345