Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death

被引：55

作者：

Martin, Vanesa ^{[1
]}

Garcia-Santos, Guillermo

Rodriguez-Blanco, Jezabel

Casado-Zapico, Sara

Sanchez-Sanchez, Ana

Antolin, Isaac

Medina, Maria ^{[2
,3
]}

Rodriguez, Carmen

机构：

[1] Fac Med, Dept Morfol & Biol Celular, Oviedo 33006, Spain

[2] Univ Oviedo, Fac Med, Area Fisioterapia, Dept Cirugia, Oviedo, Spain

[3] Hosp Jove, Serv Rehabil, Principado De Asturias, Spain

来源：

CANCER LETTERS | 2010年 / 287卷 / 02期

关键词：

Melatonin; Glioma; TRAIL; Apoptosis; Death receptors; FACTOR-RELATED APOPTOSIS; TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; CENTRAL-NERVOUS-SYSTEM; PROSTATE-CANCER CELLS; BCL-2; OVEREXPRESSION; IONIZING-RADIATION; BREAST-CANCER; IN-VITRO; INHIBITION;

D O I：

10.1016/j.canlet.2009.06.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found that melatonin effectively increase cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells. The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease in the antiapoptotic proteins survivin and bcl-2 levels. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：216 / 223

页数：8

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