Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats

被引：4
|
作者：
Herzig, Volker [1 ]
Schmidt, Werner J. [1 ]
机构：
[1] Univ Tubingen, Abt Neuropharmakol, Inst Zool, D-72076 Tubingen, Germany
来源：
ADDICTION BIOLOGY | 2007年 / 12卷 / 3-4期
关键词：
amygdala; cannulation effect; cocaine; conditioned place preference expression; locomotion; microinfusion; EXCITOTOXIC LESIONS; SEEKING BEHAVIOR; MICRODIALYSIS;
D O I：
10.1111/j.1369-1600.2007.00060.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of transient inactivation of the amygdala on expression of cocaine conditioned place preference (CPP) and locomotion was studied. We found that rats with bilateral but not unilateral amygdala cannula placement exhibited increased CPP expression during a vehicle and a cocaine test as well as increased cocaine-induced hyper-locomotion. We discuss the observed effects as being caused by the cannulation per se and we conclude that the applied cannulation produced an increased responsiveness of the amygdala by a yet undetermined mechanism.
引用
收藏
页码：478 / 481
页数：4
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