Synthetic studies on indoles and related compounds .39. New strategy for indole synthesis from ethyl pyrrole-2-carboxylate

被引：0

作者：

Tani, M ^{[1
]}

Ariyasu, T ^{[1
]}

Ohtsuka, M ^{[1
]}

Koga, T ^{[1
]}

Ogawa, Y ^{[1
]}

Yokoyama, Y ^{[1
]}

Murakami, Y ^{[1
]}

机构：

[1] TOHO UNIV, SCH PHARMACEUT SCI, FUNABASHI, CHIBA 274, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 01期

关键词：

pyrrole; beta-acylation; cyclization; indole; bromination; dehydrobromination;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a synthetic application of the previously reported C-4-acylation of ethyl pyrrole-2-carboxylate (1), a new strategy for indole synthesis was developed, Ethyl pyrrole-2-carboxylate (1) was allowed to react with succinic anhydride or 3-methoxycarbonylpropionyl chloride to give, in good yield, a C-4-succinyl derivative of 1, which was converted into ethyl 7-oxo-4,5,6,7-tetrahydroindole-2-carboxylate (6) as a key intermediate for indole synthesis, Starting from 6, several indoles functionalized on the benzene moiety were synthesized.

引用

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页码：55 / 61

页数：7

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