High-dose intravenous immunoglobulin therapy improved muscle strength in a patient with multifocal motor neuropathy and antibodies against the glycolipid LK1

We report improvement in muscle strength in a patient with multifocal motor neuropathy (MMN) when Given high-dose intravenous immunoglobin (i,v.-Ig) treatment, The patient had asymmetrical limb weakness, atrophy and absent or weak reflexes, but no sensory disturbances. Neurography showed multiple conduction blocks in peripheral motor nerves but no sensory nerve abnormalities, Serum and anti-GM1 antibodies were not found, however; the patient had serum antibodies against the glycolipid LK1, an epitope found bath in glycolipid and also in some glycoproteins in peripheral nerve myelin. Muscle strength improved 5 days after i,v,-Ig therapy, and tasted about 10 weeks, Repeated courses of treatment resulted in similar improvement, This is, to our knowledge, the first patient reported with MMN found to have antibodies against the glycolipid LK1.