Oncolytic parvoviruses as cancer therapeutics

被引：86
|
作者：
Rommelaere, Jean [1 ,2 ]
Geletneky, Karsten [1 ,2 ,3 ]
Angelova, Assia L. [1 ,2 ,4 ]
Daeffler, Laurent [1 ,2 ]
Dinsart, Christiane [1 ,2 ]
Kiprianova, Irina [1 ,2 ]
Schlehofer, Joerg R. [1 ,2 ]
Raykov, Zahari [1 ,2 ]
机构：
[1] German Canc Res Ctr, Div Tumor Virol, D-69120 Heidelberg, Germany
[2] French Natl Inst Hlth & Med Res, Canc Virotherapy Unit, D-69120 Heidelberg, Germany
[3] Univ Heidelberg Hosp, Dept Neurosurg, D-69120 Heidelberg, Germany
[4] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Dept Virol, BG-1113 Sofia, Bulgaria
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 2-3期
关键词：
Parvoviruses; Oncosuppression; Oncolysis; Immunomodulation; Cancer immunotherapy; Cancer virotherapy; Clinical trial; MINUTE VIRUS; PANCREATIC-CARCINOMA; IN-VITRO; CELLS; MICE; H-1; THERAPY; TUMORS; SUPPRESSION; IMPROVEMENT;
D O I：
10.1016/j.cytogfr.2010.02.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：185 / 195
页数：11
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