Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines

被引：31

作者：

Hoang Le Tuan Anh ^{[1
]}

Nguyen Thi Cuc ^{[1
]}

Bui Huu Tai ^{[1
,2
]}

Pham Hai Yen ^{[1
]}

Nguyen Xuan Nhiem ^{[1
]}

Do Thi Thao ^{[3
]}

Nguyen Hoai Nam ^{[1
]}

Chau Van Minh ^{[1
]}

Phan Van Kiem ^{[1
]}

Kim, Young Ho ^{[2
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi 10000, Vietnam

[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[3] Vietnam Acad Sci & Technol, Inst Biotechnol, Hanoi 10000, Vietnam

来源：

MOLECULES | 2015年 / 20卷 / 01期

关键词：

anti-cancer agent; chromonylthiazolidine; Paeonia lactiflora; paeonol; selective cytotoxicity; semi-synthesis; POTENTIAL ANTICANCER AGENTS; ANTIPROLIFERATIVE ACTIVITY; THERAPY;

D O I：

10.3390/molecules20011151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 +/- 3.6 mu g/mL) and breast cancer (IC50 32.8 +/- 1.4 mu g/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents.

引用

页码：1151 / 1160

页数：10

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