Central excitation and inhibitory mechanisms and neuroplasticity are also manifested in trigeminal nociceptive pathways

Central sensitization and related neurochemical mechanisms are also induced in V nociceptive pathways after craniofacial injury or inflammation. Their characteristics raise additional possibilities that may explain some of the phenomena outlined by CODERRE & KATZ, DICKENSON, and WIESENFELD-HALLIN et al. They also underscore the need for therapeutic approaches to reduce nociceptive inputs to the CNS or their neuroplastic effects which can potentially enhance post-traumatic pain.