Minimizing Undesirable Epitope Immunodominance on HIV-1 Env Immunogens through Rational Immunogen Modification

被引:0
|
作者
McGuire, Andrew T. [1 ]
Dreyer, Anita M. [1 ]
Carbonetti, Sara [1 ]
Glenn, Jolene A. [1 ]
Scheid, Johannes F. [2 ]
Mouquet, Hugo [2 ]
Stamatatos, Leo [1 ]
机构
[1] Seattle Biomed, Seattle, WA USA
[2] Rockefeller Univ, New York, NY 10021 USA
关键词
D O I
10.1089/aid.2014.5004.abstract
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
OA01.05
引用
收藏
页码:A8 / A8
页数:1
相关论文
共 50 条
  • [1] Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?
    Klasse, P. J.
    Ozorowski, Gabriel
    Sanders, Rogier W.
    Moore, John P.
    CELL HOST & MICROBE, 2020, 27 (04) : 507 - 518
  • [2] Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope
    Morgan E. Abernathy
    Harry B. Gristick
    Jost Vielmetter
    Jennifer R. Keeffe
    Priyanthi N. P. Gnanapragasam
    Yu E. Lee
    Amelia Escolano
    Rajeev Gautam
    Michael S. Seaman
    Malcolm A. Martin
    Michel C. Nussenzweig
    Pamela J. Bjorkman
    npj Vaccines, 6
  • [3] Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope
    Abernathy, Morgan E.
    Gristick, Harry B.
    Vielmetter, Jost
    Keeffe, Jennifer R.
    Gnanapragasam, Priyanthi N. P.
    Lee, Yu E.
    Escolano, Amelia
    Gautam, Rajeev
    Seaman, Michael S.
    Martin, Malcolm A.
    Nussenzweig, Michel C.
    Bjorkman, Pamela J.
    NPJ VACCINES, 2021, 6 (01)
  • [4] Throughput Screening of HIV-1 Broad Neutralizing Antibodies and Env Immunogens
    Yang, Yongping
    Kwong, Peter D.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 400 - 400
  • [5] Identification of Dispersed Glycans on HIV-1 Env Trimer and Design of Related Immunogens
    Stewart-Jones, Guillaume B. E.
    Soto, Cinque
    Zhou, Tongqing
    Kwong, Peter D.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 329 - 329
  • [6] Rational modifications of HIV-1 envelope glycoproteins for immunogen design
    Phogat, S.
    Wyatt, R.
    CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (02) : 213 - 227
  • [7] Designing occluded-open Env-based immunogens for HIV-1
    DeLaitsch, Andrew T.
    Liendo, Nathaniel
    Bjorkman, Pamela J.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 472A - 472A
  • [8] Vertical T cell immunodominance and epitope entropy determine HIV-1 escape
    Liu, Michael K. P.
    Hawkins, Natalie
    Ritchie, Adam J.
    Ganusov, Vitaly V.
    Whale, Victoria
    Brackenridge, Simon
    Li, Hui
    Pavlicek, Jeffrey W.
    Cai, Fangping
    Rose-Abrahams, Melissa
    Treurnicht, Florette
    Hraber, Peter
    Riou, Catherine
    Gray, Clive
    Ferrari, Guido
    Tanner, Rachel
    Ping, Li-Hua
    Anderson, Jeffrey A.
    Swanstrom, Ronald
    Chavi, Core B.
    Cohen, Myron
    Karim, Salim S. Abdool
    Haynes, Barton
    Borrow, Persephone
    Perelson, Alan S.
    Shaw, George M.
    Hahn, Beatrice H.
    Williamson, Carolyn
    Korber, Bette T.
    Gao, Feng
    Self, Steve
    McMichael, Andrew
    Goonetilleke, Nilu
    JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (01): : 380 - 393
  • [9] Selected HIV-1 Env Trimeric Formulations Act as Potent Immunogens in a Rabbit Vaccination Model
    Heyndrickx, Leo
    Stewart-Jones, Guillaume
    Jansson, Marianne
    Schuitemaker, Hanneke
    Bowles, Emma
    Buonaguro, Luigi
    Grevstad, Berit
    Vinner, Lasse
    Vereecken, Katleen
    Parker, Joe
    Ramaswamy, Meghna
    Biswas, Priscilla
    Vanham, Guido
    Scarlatti, Gabriella
    Fomsgaard, Anders
    PLOS ONE, 2013, 8 (09):