Direct synthesis with melt polycondensation and microstructure analysis of poly(L-lactic acid-co-glycolic acid)

被引：53

作者：

Gao, QW ^{[1
]}

Lan, P ^{[1
]}

Shao, HL ^{[1
]}

Hu, XC ^{[1
]}

机构：

[1] Donghua Univ, State Key Lab Modificat Fibers & Polymer Mat, Coll Mat Sci & Engn, Shanghai 200051, Peoples R China

来源：

POLYMER JOURNAL | 2002年 / 34卷 / 11期

关键词：

direct synthesis; microstructure; poly(L-lactic acid-co-glycolic acid); poly(L-lactic acid); poly(D; L-lactic acid);

D O I：

10.1295/polymj.34.786

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

High-molecular-weight poly((L)-lactic acid-co-glycolic acid) (PLGA) was prepared through melt polymerization from glycolic acid (GA) and (L)-lactic acid ((L)-LA) and then characterized. High resolution H-1 and C-13 NMR were performed for microstructure analysis of polymer. The solubility in chloroform, compositions, and sequence lengths of PLGA suggest higher reactivity of GA compared with (L)-LA and shortening GA blocks with reaction time. The racemization of (L)-LA blocks and transesterification in PLGA are enhanced by increase of GA fractions. PLGA (90/10) samples show crystallization of relatively long (L)-LA sequences in copolymer chains and the absence of the crystallization of GA blocks. All these results demonstrate the influence of racemization and transesterification on the microstructure of PLGA.

引用

页码：786 / 793

页数：8

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