Sirtuin 2 as a possible therapeutic target in Cancer

Due to different functions of Sirtuin 2 (SIRT2) in many biological and cellular processes, it has been speculated that SIRT2 can be a good therapeutic target for cancers and other diseases like inflammation and neurodegenerative disorders. But there are several conflicting reports regarding the selectivity and specificity of SIRT2 as a target for drugs. Target validation studies are important for establishing and developing novel therapies against cancer. SIRT2 as a therapeutic target in cancer has not been established. Thus, potent and specific inhibitors for SIRT2 are necessary for not only elucidating SIRT2 functions but also for target validation against diseases including cancer. Unfortunately, few of their structural information are available and the procedure to optimize structure based selective inhibitors of SIRT2 remains mostly indefinable.