Triazolam-induced amnesia and the word-frequency effect in recognition memory: Support for a dual process account

Acute administration of the benzodiazepine hypnotic drug triazolam induces temporary amnesia. The present double-blind, placebo-controlled, repeated-measures experiment used triazolam-induced amnesia to test predictions of the dual process account of the word frequency effect in recognition memory (the reliably observed finding that low frequency words have higher hit rates and lower false alarm rates than high frequency words) in 28 healthy adult volunteers. According to the dual process account (Joordens Hockley, 2000; Reder et al., 2000), the hit rate component of the word frequency effect is driven by recollection, whereas the false alarm rate component is driven by familiarity. Based on evidence that triazolam produces relatively greater impairment in recollection-based recognition than in familiarity-based recognition, the dual process account would predict that the hit rate effect should be eliminated or reversed in the triazolam condition, but that the false alarm rate effect should be relatively unaffected by drug condition. These predictions were confirmed. (C) 2003 Elsevier Science (USA). All rights reserved.