Allosteric drugs acting at muscarinic acetylcholine receptors

被引：8
|
作者：
Waelbroeck, M [1 ]
机构：
[1] Free Univ Brussels, Sch Med, Dept Biochem & Nutr, B-1070 Brussels, Belgium
来源：
NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 3-4期
关键词：
muscarinic receptors; allosteric drugs; facilitator effects; subtype selectivity; gallamine; alcuronium;
D O I：
10.1023/A:1022888332221
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The binding properties of muscarinic acetylcholine receptors are affected by various drugs acting at a second (allosteric) binding site, usually (but not always) at supratherapeutic concentrations. Allosteric drugs acting at GABA receptors present advantages over competitive drugs; this explains the interest raised by allosteric effects on muscarinic receptors. A theoretical and practicable definition of allosteric drugs acting at muscarinic receptors will be given in this work, together with a summary of recent data concerning, the number, position, and structural requirements of their binding sites.
引用
收藏
页码：419 / 422
页数：4
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