An Approach to One-Pot Regioselective Synthesis of Indenones through Palladium-Catalyzed Annulation in Water

被引：24
|
作者：
Ramesh, Karu [1 ]
Satyanarayana, Gedu [1 ]
机构：
[1] IIT, Kandi 502285, Telangana, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 30期
关键词：
Pd catalysis; Domino reactions; Indenones; Annulation; Neolignans; Water chemistry; Green chemistry; CARBONYLATIVE CYCLIZATION REACTIONS; MEOTF-INDUCED CARBOANNULATION; C-H BOND; EFFICIENT SYNTHESIS; INTERNAL ALKYNES; ACCESS; ARYL; CARBOPALLADATION; ALCOHOLS; KETONES;
D O I：
10.1002/ejoc.201800591
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthesis of indenones is presented. The process involves palladium-catalyzed annulation of ortho-halobenzaldehydes with internal alkynes. Notably, it proceeded successfully in water as the sole, and green, solvent. Significantly, unlike in earlier reports, this protocol showed excellent regioselectivity with unsymmetrical alkylarylacetylenes. Further, the strategy was extended to a one-pot synthesis of a neolignan natural product.
引用
收藏
页码：4135 / 4146
页数：12
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