Disseminated adenovirus infection in a patient with a hematologic malignancy: a case report and literature review

Human adenoviruses cause a wide spectrum of illnesses, including invasive infections, in immunocompromised hosts. We report a case of disseminated adenovirus infection following unrelated cord-blood transplantation in a 46-year-old male with a lymphoma. A review of the literature on disseminated adenovirus infections in adult patients with hematopoietic stem cell transplantation has also been included. Despite antiviral therapy, the mortality rate in hematopoietic stem cell transplantation recipients with a disseminated adenovirus infection is as high as 72%, and estimating the risk of human adenovirus infection in a timely manner is crucial to improving outcomes. Lay abstract: Human adenoviruses are common viruses that cause a range of illness such as bronchitis, gastroenteritis and conjunctivitis. We recently experienced a case of disseminated adenovirus infection following hematopoietic stem cell transplantation in a patient with a lymphoma who received chemotherapy. Although disseminated adenovirus infection is not a rare disease in immunocompromised patients, it is noteworthy that its mortality remains high and it may not frequently occur. Therefore, this work provides a case presentation and a review of disseminated adenovirus infection in patients with hematopoietic stem cell transplantation in order to aid our understanding of the nature of illness of human adenovirus infections in immunocompromised patients.