2-methoxyestradiol: An endogenous antiangiogenic and antiproliferative drug candidate

被引:226
|
作者
Pribluda, VS [1 ]
Gubish, ER [1 ]
Gubish, ER [1 ]
LaVallee, TM [1 ]
Treston, A [1 ]
Swartz, GM [1 ]
Green, SJ [1 ]
机构
[1] Entremed Inc, Rockville, MD 20850 USA
关键词
2-methoxyestradiol; angiogenesis; endothelial cells; antiangiogenic therapy; cancer steroid;
D O I
10.1023/A:1026543018478
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2-Methoxyestradiol, once considered an inacitve end-metabolite of estradiol, has recently emerged as a very promising agent for cancer treatment. It is orally active in a wide range of tumor models, and inhibits tumor growth at doses showing non clinical signs of toxicity. 2ME(2) targets both the tumor cell and endothelial cell compartments by inducing apoptosis in rapidly proliferating cells and inhibiting blood vessel formation at several stages in the angiogenic cascade. Moreover, the ability of 2ME(2) to inhibit metastic spread in several models adds to its therapeutic value for cancer treatment at various stages of the disease. Though the mechanism of action is still undefined, several potential molecular targets and pathways of activation have been suggested.
引用
收藏
页码:173 / 179
页数:7
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