Immunohistochemical Distribituon of COX-1, COX-2, and TGFβ-1 in the Duodenum of Rats Treated with Capsaicin

被引：0

作者：

Bakir, Buket ^{[1
]}

Elis Yildiz, Sevda ^{[2
]}

Karadag Sari, Ebru ^{[3
]}

Asker, Hasan ^{[3
]}

Nazli, Mumtaz ^{[4
]}

机构：

[1] Namik Kemal Univ, Dept Histol Embryol, Fac Vet Med, TR-59000 Tekirdag, Turkey

[2] Kafkas Univ, Sch Hlth Sci, TR-36040 Kars, Turkey

[3] Kafkas Univ, Fac Vet Med, Dept Histol Embryol, TR-36040 Kars, Turkey

[4] Mugla Sitki Kocman Univ, Dept Histol Embryol, Fac Med, TR-48000 Mugla, Turkey

来源：

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | 2016年 / 22卷 / 03期

关键词：

Capsaicin; Cyclooxygenase; Duodenum; Transforming growth factor beta-1; GROWTH-FACTOR-ALPHA; EPITHELIAL-CELLS; FACTOR-BETA; CYCLOOXYGENASE; GENE-EXPRESSION; PAIN MANAGEMENT; SMALL-INTESTINE; MESSENGER-RNA; RECEPTOR; MICE;

D O I：

10.9775/kvfd.2015.14559

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The purpose of this study was to investigate the effects of capsaicin on the duodenal distribution of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Transforming growth factor beta-1 (TGF beta-1) in rats. Rats were divided into two groups (n = 10 in each group). Experimental group treated with capsaicin (1 mg/kg, subcutaneously) was injected in 10% ethanol, 1% Tween and 80% distilled water everyday for a period of one week and in not injected control group. Localisations of COX-1, COX-2 and TGF beta-1 were observed in villus and crypt ephitelial cells, and smooth muscle cells. In conclusion, in this study, capsaicin administration was found to increase the release of COX-1 and COX-2, and TGF beta-1.

引用

页码：333 / 338

页数：6

共 50 条

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