The traditional mathematics teaching mode has been insufficient to meet the mathematics learning needs of students who are at different levels according to the characteristics of diversification and difference of students' mathematics learning process at the current stage. So it is very necessary to research on the difference of the students' learning effect in the mathematics teaching reform mode. This paper describes the present situation of the difference between the mathematics teaching reform mode, discusses the importance and necessity of the study of the difference in mathematics teaching reform mode and puts forward some opinions and suggestions on how to enhance the application of difference in the mathematics teaching mode in the actual teaching to contribute to the integration of the current mathematics teaching resources, reposition and analyze the actual application of difference mode in the mathematics teaching reform, ensure the realization of the mathematics teaching goal, help to shape the students' mathematics thinking mode and make full use of the students' divergent thinking ability. With the continuous increase of the internationalization process, the demand for talent also shifts to the comprehensive direction. In order to adapt to the changing social needs and transport various talents for the society, the reform of teaching mode has become the key, especially the reform of mathematics teaching mode plays an important component in the teaching mode.