Hospitalized mortality and vascular events in CKD patients after receiving percutaneous coronary intervention: a nationwide cohort study

Background: Cardiovascular disease is the crucial morbidity and mortality in patients with chronic kidney disease (CKD). However, clinical outcomes of mortality and vascular events in patients with CKD and end-stage renal disease (ESRD) on dialysis after receiving percutaneous coronary intervention (PCI) for cardiovascular disease have remained unclear in the literature, as compared with the general population. Our aim was to determine the post-PCI hospitalized mortality and vascular events in patients with CKD and ESRD in Taiwan. Methods: Using Taiwan National Health Institutes Research Database, we identified patients who received PCI from 2010-2011. Of a total of 2,273 patients without CKD, 297 patients with CKD, and 125 patients with ESRD on dialysis were enrolled in this study. Main outcomes were the post-PCI hospitalized mortality and vascular events. Results: There was higher post-PCI hospitalized mortality in patients with CKD and with ESRD-on-dialysis than in patients without CKD. Post-PCI vascular events in both patients with CKD and with ESRD on dialysis were significantly higher than those in patients without CKD [adjusted odds Ratio (OR) = 1.936; 95% CI, 1.085 to 4.407, P = 0.026, and adjusted OR = 6.220; 95% CI, 2.901 to 13.337, P<0.001, respectively]. Conclusion: We need to pay attention to the increased post-PCI hospitalized mortality and vascular events in patients with CKD and with ESRD on dialysis.