Antitumor activities of EGFR/HER2/HER4 kinase inhibitor S-222611 in the experimental brain metastases of HER2-positive breast cancer

被引:0
|
作者
Hirata, Michinari
Tanaka, Yukari
Shinonome, Satomi
Yamada, Tomomi
Torii, Mikinori
Nezasa, Kenichi
Tanaka, Hidekazu
机构
关键词
D O I
10.1158/1538-7445.AM2017-4073
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4073
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Distribution analysis of S-222611 in brain metastases of HER2-positive breast cancer by quantitative imaging mass spectrometry: prospect for antitumor activity of EGFR/HER2/HER4 kinase inhibitor S-222611 against brain metastases
    Tanaka, Yukari
    Hirata, Michinari
    Shinonome, Satomi
    Matsumoto, Mitsunobu
    Nogami, Wataru
    Torii, Mikinori
    Nezasa, Ken-ichi
    Tanaka, Hidekazu
    CANCER RESEARCH, 2017, 77
  • [2] Phase I expansion of S-222611, a reversible inhibitor of EGFR and HER2, in advanced solid tumors, including HER2-positive breast cancer patients with brain metastases
    Baird, R. D.
    Arkenau, H-T
    Deva, S.
    Cresti, N.
    Garcia-Corbacho, J.
    Hogarth, L.
    Frenkel, E.
    Kawaguchi, K.
    Arimura, A.
    Donaldson, K.
    Posner, J.
    Sarker, D.
    Jodrell, D.
    Plummer, R.
    Spicer, J.
    Italiano, A.
    CANCER RESEARCH, 2016, 76
  • [3] A phase I/II of S-222611, a reversible EGFR and HER2 inhibitor, combined with trastuzumab plus /- chemotherapy in patients with HER2-positive metastatic breast cancer
    Rafii, S.
    Macpherson, I.
    Baird, R.
    Saggese, M.
    Spiliopoulou, P.
    Kumar, S.
    Italiano, A.
    Bonneterre, J.
    Campone, M.
    Cresti, N.
    Posner, J.
    Takeda, Y.
    Arimura, A.
    Spicer, J.
    CANCER RESEARCH, 2017, 77
  • [4] Phase I trial of S-222611, a dual tyrosine kinase inhibitor of EGFR and HER2, with preliminary evidence of efficacy in patients (pts) with heavily-pretreated HER2-positive metastatic breast cancer
    Baird, R. D.
    Cresti, N.
    Beddowes, E.
    Saggese, M.
    Flynn, M.
    Corbacho, J. Garcia
    Gao, F.
    Lemech, C.
    Donaldson, K.
    Posner, J.
    Kawabata, I.
    Forster, M.
    Arkenau, H. T.
    Plummer, R.
    Jodrell, D.
    Spicer, J.
    CANCER RESEARCH, 2013, 73
  • [5] S-222611, a potent, orally active small molecule inhibitor of EGFR and HER2: in vitro kinase inhibition and antitumor activity
    Hirata, Michinari
    Tanaka, Hidekazu
    Dohi, Keiji
    Iguchi, Motofumi
    Wada, Tohru
    Matsuo, Kenji
    Kume, Masaharu
    Omori, Naoki
    Tada, Yukio
    Orita, Satoshi
    Abe, Kenji
    Arimura, Akinori
    Matsuo, Yoshiyuki
    Kato, Akira
    CANCER RESEARCH, 2009, 69
  • [6] S-222611, a potent, orally active small molecule inhibitor of EGFR and HER2: In vivo antitumor effects
    Iguchi, Motofumi
    Tanaka, Hidekazu
    Wada, Tohru
    Hojo, Kanji
    Shinonome, Satomi
    Sato, Norihito
    Nezasa, Ken-ichi
    Orita, Satoshi
    Abe, Kenji
    Arimura, Akinori
    Matsuo, Yoshiyuki
    Kato, Akira
    CANCER RESEARCH, 2009, 69
  • [7] Brain metastases in HER2-positive breast cancer
    Lin, Nancy U.
    LANCET ONCOLOGY, 2013, 14 (03): : 185 - 186
  • [8] HER2Δ16 expression in HER2-positive breast cancer
    De Yao, Jocelyn Torres
    Sun, Danyu
    Galehouse, Donna
    Shorten, Scott
    Haller, Nairmeen
    Rehmus, Esther Hoogland
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [9] HER2Δ16 expression in HER2-positive breast cancer
    De Yao, Jocelyn Torres
    Sun, Danyu
    Galehouse, Donna
    Shorten, Scott
    Haller, Nairmeen Awad
    Rehmus, Esther Hoogland
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (26)
  • [10] Phase I expansion of S-222611, a reversible inhibitor of EGFR and HER2, in advanced solid tumors, including patients with brain metastases.
    Deva, Sanjeev
    Baird, Richard D.
    Cresti, Nicola
    Garcia-Corbacho, Javier
    Hogarth, Linda
    Frenkel, Eugene P.
    Kawaguchi, Keiko
    Arimura, Akinori
    Donaldson, Kirsteen
    Posner, John
    Sarker, Debashis
    Jodrell, Duncan Ian
    Plummer, Ruth
    Spicer, James F.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)