A Multicomponent One-pot Synthesis of 3-Cyanopyridine Derivatives

被引：0
|
作者：
Al-Ghorbani, Mohammed [1 ,2 ]
Gouda, Moustafa A. [1 ,3 ]
Qurban, Jihan [4 ]
机构：
[1] Taibah Univ, Ulla Sci & Arts Coll, Dept Chem, Medina, Saudi Arabia
[2] Thamar Univ, Coll Educ, Dept Chem, Dhamar, Yemen
[3] Mansoura Univ, Fac Sci, Dept Chem, El Gomhoria St, Mansoura, Egypt
[4] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca, Saudi Arabia
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 01期
关键词：
3-Cyanopyridine; Malononitrile; Ethyl cyanoacetate; Multicomponent one-pot synthesis; DISCOVERY; INHIBITORS; DESIGN;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient method was developed for synthesis of 2-amino-3-cyanopyridine and 3-cyanopyridine-2(1H)-ones (4a-e, 6a-e) from 2,6-dimethylheptan-4-one, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in the presence of ammonium acetate in good to excellent yields and the structure of targets compounds was characterized by Fourier-transform infrared and H-1 and C-13 nuclear magnetic resonance and mass spectral and elemental analytical data.
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页码：77 / 80
页数：4
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