Mast cell tryptase promotes breast cancer migration and invasion

被引：50

作者：

Xiang, Meng ^{[1
]}

Gu, Yiping ^{[1
]}

Zhao, Fengdi ^{[1
]}

Lu, Hong ^{[2
]}

Chen, Sifeng ^{[1
]}

Yin, Lianhua ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Dept Physiol & Pathophysiol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Biochem, Shanghai 200032, Peoples R China

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 03期

关键词：

tryptase; breast cancer; metastasis; matrix metalloproteinase-2; mast cell; MATRIX-METALLOPROTEINASE EXPRESSION; ANTI-TRYPTASE; HYPOXIA; ANGIOGENESIS; METASTASIS; CHYMASE; GROWTH;

D O I：

10.3892/or_0000676

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been reported that the number of typtase-positive mast cells was significantly greater in breast peri-tumoral tissue. However, the significance of tryptase in tumor growth and metastasis is unknown. Tryptase in surgical breast cancer samples was stained by immunohistochemistry. The effects of tryptase on breast cancer proliferation, invasion and migration were observed in vitro. We found,found significantly more tryptase in peritumoral tissue than in normal breast tissue. The increased tryptase was associated with higher tumor grade and more lymph node metastasis. Tryptase promoted the invasion and migration of breast cancer cells along, with activation of matrix metalloproteinase-2. Tryptase did not affect the proliferation Of the Cells. Our results indicate that tryptase promotes breast cancer migration and invasion.

引用

页码：615 / 619

页数：5

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