Comparison of outcomes of haploidentical donor hematopoietic stem cell transplantation supported by third-party cord blood with HLA-matched unrelated donor transplantation

被引：12

作者：

Lyu, Hairong ^{[1
]}

Lu, Wenyi ^{[1
]}

Yao, Jianfeng ^{[2
]}

Xiao, Xia ^{[1
]}

Li, Qing ^{[1
]}

Wang, Jia ^{[1
]}

Mu, Juan ^{[1
]}

Qi, Yao ^{[1
]}

Zhu, Haibo ^{[1
]}

Jiang, Yili ^{[1
]}

Li, Xin ^{[1
]}

Meng, Juanxia ^{[1
]}

Yuan, Ting ^{[1
]}

He, Xiaoyuan ^{[1
]}

Jiang, Erlie ^{[2
]}

Han, Mingzhe ^{[2
]}

Zhao, Mingfeng ^{[1
]}

机构：

[1] Tianjin First Ctr Hosp, Dept Hematol, Tianjin, Peoples R China

[2] Peking Union Med Coll & Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, Hematopoiet Stem Cell Transplantat Ctr, 288 Nanjing Rd, Tianjin 300060, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2020年 / 61卷 / 04期

关键词：

Haploidentical donor; stem cell transplantation; cord blood; GRAFT; REMISSION;

D O I：

10.1080/10428194.2019.1695053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous study indicated that co-infusion of cord blood cells may potentially improve the outcome of haploidentical donor (HID) transplantation. In this study, we analyzed the outcomes of patients who underwent HID transplantation supported by cord blood when compared with HLA-matched unrelated donor (URD) transplantation. Starting in 2015, 40 patients with hematopoietic malignancies underwent HID transplantation and 26 patients underwent URD transplantation. Hematopoietic recovery, the incidences of grade II-IV acute graft-versus-host disease (GVHD) and chronic GVHD was comparable in the two groups. At two year, the relapse risk in HID group was significantly lower than in URD group (RR 4.630; 95%CI, 1.081-19.839; p = .039). Moreover, HID group have prolonged PFS (RR 2.642; 95%CI, 1.046-6.672; p = .040). In conclusion, HID transplantation supported by cord blood results in better outcomes compared with URD transplantation and it might be a favorable alternative to a HLA-matched URD transplantation.

引用

页码：840 / 847

页数：8

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