Angucyclines containing β-D-glucuronic acid from Streptomyces sp. KCB15JA151

被引：2
|
作者：
Kim, Gil Soo [1 ,2 ]
Jang, Jun-Pil [1 ]
Oh, Tae Hoon [1 ,3 ]
Kwon, Mincheol [1 ,2 ]
Lee, Byeongsan [1 ,3 ]
Lee, Jung-Sook [4 ]
Ko, Sung-Kyun [1 ]
Hong, Young-Soo [1 ,2 ]
Ahn, Jong Seog [1 ,2 ]
Jang, Jae-Hyuk [1 ,2 ]
机构：
[1] Korea Res Inst Biosci & Biotechnol, Anticanc Agent Res Ctr, Cheongju 28116, South Korea
[2] Univ Sci & Technol, KRIBB Sch Biosci, Dept Biomol Sci, Daejeon 34113, South Korea
[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea
[4] Korea Res Inst Biosci & Biotechnol, Korean Collect Type Cultures, Jeongeup 56212, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2021年 / 48卷
基金：
新加坡国家研究基金会;
关键词：
Streptomyces sp; Angucycline; beta-D-Glucuronic acid; PROTEIN TARGETS; DOCKING; BIOSYNTHESIS;
D O I：
10.1016/j.bmcl.2021.128237
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two angucyclines, pseudonocardones D (1) and E (2), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ER alpha antagonist.
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页数：5
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