Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3

被引：104
|
作者：
Cheng, Y
Poulos, NE
Lung, ML
Hampton, G
Ou, BX
Lerman, MI
Stanbridge, EJ
机构：
[1] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA
[2] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong
[3] Genos Biosci Inc, La Jolla, CA 92037 USA
[4] Sun Yatsen Univ Med Sci, Inst Canc, Guangzhou, Peoples R China
[5] NCI, Frederick, MD 21702 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 06期
关键词：
D O I：
10.1073/pnas.95.6.3042
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.
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收藏
页码：3042 / 3047
页数：6
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