Imaging of sleep disorders in pre-Parkinsonian syndromes

被引：4

作者：

Ota, Yoshiaki ^{[1
]}

Kanel, Prabesh ^{[2
,3
,4
]}

Bohnen, Nicolaas ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Michigan, Div Neuroradiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Morris K Udall Ctr Excellence Parkinsons Dis Res, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Parkinsons Fdn, Res Ctr Excellence, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[6] VAAAHS, GRECC Neurol Serv, Ann Arbor, MI USA

来源：

CURRENT OPINION IN NEUROLOGY | 2022年 / 35卷 / 04期

关键词：

cardiac metaiodobenzylguanidine; diffusion tensor imaging; dopamine transporter imaging; single-photon emission computerized tomography; functional MRI; neuromelanin-sensitive MRI; Parkinson's disease; PET; prodromal clinical marker; rapid eye movement sleep disorder; PREDICTS EARLY TRANSITION; BEHAVIOR DISORDER; COERULEUS/SUBCOERULEUS COMPLEX; NEURODEGENERATIVE DISEASE; FUNCTIONAL CONNECTIVITY; DIFFERENTIAL-DIAGNOSIS; PRODROMAL DEMENTIA; SUBSTANTIA-NIGRA; GRAY-MATTER; BLOOD-FLOW;

D O I：

10.1097/WCO.0000000000001084

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of review Neuroimaging has been advanced in the last years and enabled clinicians to evaluate sleep disorders, especially isolated rapid eye movement sleep disorder (iRBD), which can be seen in alpha-synucleinopathies. iRBD is the best prodromal clinical marker for phenoconversion to these neurodegenerative diseases. This review aims to provide an update on advanced neuroimaging biomarkers in iRBD. Recent findings Advanced structural MRI techniques, such as diffusion tensor imaging and functional MRI, neuromelanin-sensitive MRI, and scintigraphic neuroimaging such as cholinergic PET, dopamine transporter imaging - single-photon emission computerized tomography, perfusional single-photon emission computerized tomography, and cardiac metaiodobenzylguanidine can provide diagnostic and prognostic imaging biomarkers for iRBD, in isolation and more robustly when combined. New advanced neuroimaging can provide imaging biomarkers and aid in the appropriate clinical assessment and future therapeutic trials.

引用

页码：443 / 452

页数：10

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