Long-range enhancement of β-globin gene expression is dependent on GT motifs residing in the HS3 core element of the locus control region.

被引：0
|
作者：
Navas, PA [1 ]
Stergachis, AB [1 ]
Sheffer, HH [1 ]
Ye, X [1 ]
Stafford, M [1 ]
Stamatoyannopoulos, G [1 ]
机构：
[1] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA
来源：
BLOOD | 2004年 / 104卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1222
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页码：345A / 345A
页数：1
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  • [1] Long-range enhancement of β-globin gene expression is dependent on GT motifs residing in the HS3 core element of the locus control region.
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  • [2] Multiple hypersensitive sites comprise a functional "unit" for HS3 of the β-globin locus control region.
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  • [10] The 5′ HS3 core element of the β-globin LCR is essential for formation of an active chromatin domain in the entire β-globin gene locus in adult erythropoiesis.
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