Serum amyloid P: a systemic regulator of the innate immune response

被引：69
|
作者：
Cox, Nehemiah [1 ]
Pilling, Darrell [1 ]
Gomer, Richard H. [1 ]
机构：
[1] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2014年 / 96卷 / 05期
关键词：
neutrophil adhesion; macrophage polarization; fibrocyte differentiation; Fc gamma receptors; phagocytosis; fibrosis; INDUCED PULMONARY-FIBROSIS; FC-GAMMA RECEPTORS; C-REACTIVE PROTEIN; TUMOR-ASSOCIATED MACROPHAGES; NEUTROPHIL ELASTASE; COMPONENT; ACTIVATION; DIFFERENTIATION; POLARIZATION; FIBROCYTES;
D O I：
10.1189/jlb.1MR0114-068R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The pentraxin SAP reduces neutrophil adhesion to ECM proteins, inhibits the differentiation of monocytes into fibrocytes, attenuates profibrotic macrophages, activates the complement pathway, and promotes phagocytosis of cell debris. Together, these effects of SAP regulate key aspects of inflammation and set a threshold for immune cell activation. Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. We also discuss how there remain many unanswered questions about the role of SAP in innate immunity.
引用
收藏
页码：739 / 743
页数：5
相关论文
共 50 条
  • [1] Human Serum Amyloid P Functions as a Negative Regulator of the Innate and Adaptive Immune Responses to DNA Vaccines
    Wang, Yue
    Guo, Yingjun
    Wang, Xiaohui
    Huang, Jinfeng
    Shang, Jingli
    Sun, Shuhan
    JOURNAL OF IMMUNOLOGY, 2011, 186 (05): : 2860 - 2870
  • [2] SERUM AMYLOID A AND PENTRAXIN 3: INNATE IMMUNE RESPONSE AND DISEASE ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Assandri, R.
    Martellosio, G.
    Montanelli, A.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1324 - 1324
  • [3] Serum Amyloid P and IgG Exhibit Differential Capabilities in the Activation of the Innate Immune System in Response to Bacillus anthracis Peptidoglycan
    Girton, Alanson W.
    Popescu, Narcis I.
    Keshari, Ravi S.
    Burgett, Tarea
    Lupu, Florea
    Coggeshall, K. Mark
    INFECTION AND IMMUNITY, 2018, 86 (05)
  • [4] Microbiota-Induced Serum Amyloid A is an Important Mediator of Innate Immune Response in Zebrafish
    Koo, Ja Seol
    Kanther, Michelle
    Rawls, John F.
    Jobin, Christian
    GASTROENTEROLOGY, 2010, 138 (05) : S78 - S79
  • [5] Serum amyloid A and apolipoprotein E alter the host innate immune response elicited by malarial hemozoin
    Kassa, Fikregabrail
    Shio, Marina
    Olivier, Martin
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [6] Interleukin-15 as a potential regulator of the innate immune response
    Carson, W
    Caligiuri, MA
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1998, 31 (01) : 1 - 9
  • [7] Periodontal Inflammation Primes the Systemic Innate Immune Response
    Fine, N.
    Chadwick, J. W.
    Sun, C.
    Parbhakar, K. K.
    Khoury, N.
    Barbour, A.
    Goldberg, M.
    Tenenbaum, H. C.
    Glogauer, M.
    JOURNAL OF DENTAL RESEARCH, 2021, 100 (03) : 318 - 325
  • [8] Serum amyloid A is an innate immune opsonin for Gram-negative bacteria
    Shah, Chandrabala
    Hari-Dass, Ranjeeta
    Raynes, John G.
    BLOOD, 2006, 108 (05) : 1751 - 1757
  • [9] STING is a negative regulator of innate immune response in Cryptococcus neoformans infection
    Kobayashi, Mutsuki
    Yabe, Rikio
    Wakatsuki, Maki
    Akahori, Yukiko
    Saijo, Shinobu
    CYTOKINE, 2017, 100 : 157 - 157
  • [10] MicroRNA-146a: a dominant, negative regulator of the innate immune response
    Saba, Reuben
    Sorensen, Debra L.
    Booth, Stephanie A.
    FRONTIERS IN IMMUNOLOGY, 2014, 5
12345