Effect of pH on the Conformation of Inclusion Complexes between β-Lactam Antibiotics and β-Cyclodextrins in Aqueous Solution

被引：1
|
作者：
Yukawa, Miho [1 ]
Moriwaki, Hanae [1 ]
Murakami, Taichi [1 ]
Ikeda, Hirohito [1 ]
Iwase, Yukiko [1 ]
Aki, Hatsumi [1 ]
机构：
[1] Fukuoka Univ, Jonan Ku, Fukuoka 8140180, Japan
来源：
KOBUNSHI RONBUNSHU | 2010年 / 67卷 / 03期
关键词：
beta-Lactam Antibiotics; beta-Cyclodextrin; Inclusion Complex; Stabilization Energy; ALPHA-CYCLODEXTRIN; DERIVATIVES;
D O I：
10.1295/koron.67.192
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The inclusion complexes of two beta-lactam antibiotics, ampicillin (ABPC) and amoxicillin (AMPC), with beta-cyclodextrin in aqueous solution has been studied by semi-empirical molecular orbital method. In a strongly acid solution, two different types of complexes with a 1: 1 stoichiometry were formed. Complex_Ph, in which the phenyl ring of beta-lactam antibiotics was oriented towards the cavity of CD, and Complex_Pe, in which the penam ring was oriented towards the cavity. In neutral or basic solution, only Complex_Ph was formed. These results match the results of microcalorimetry and (1)H NMR spectroscopy.
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收藏
页码：192 / 197
页数：6
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