Effect of pH on the Conformation of Inclusion Complexes between β-Lactam Antibiotics and β-Cyclodextrins in Aqueous Solution

被引:1
|
作者
Yukawa, Miho [1 ]
Moriwaki, Hanae [1 ]
Murakami, Taichi [1 ]
Ikeda, Hirohito [1 ]
Iwase, Yukiko [1 ]
Aki, Hatsumi [1 ]
机构
[1] Fukuoka Univ, Jonan Ku, Fukuoka 8140180, Japan
关键词
beta-Lactam Antibiotics; beta-Cyclodextrin; Inclusion Complex; Stabilization Energy; ALPHA-CYCLODEXTRIN; DERIVATIVES;
D O I
10.1295/koron.67.192
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The inclusion complexes of two beta-lactam antibiotics, ampicillin (ABPC) and amoxicillin (AMPC), with beta-cyclodextrin in aqueous solution has been studied by semi-empirical molecular orbital method. In a strongly acid solution, two different types of complexes with a 1: 1 stoichiometry were formed. Complex_Ph, in which the phenyl ring of beta-lactam antibiotics was oriented towards the cavity of CD, and Complex_Pe, in which the penam ring was oriented towards the cavity. In neutral or basic solution, only Complex_Ph was formed. These results match the results of microcalorimetry and (1)H NMR spectroscopy.
引用
收藏
页码:192 / 197
页数:6
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